Cleft Palate Research Today is a free monthly online journal that collates and summarizes the latest research about Cleft Palate, including details on causes, surgery, treatment.

Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate.

Erickson RP, Karolyi IJ, Diehl SR

Department of Pediatrics/4341B, 1501 N. Campbell Avenue, P. O. Box 245073, Tucson, Arizona 85724-5073, USA. erickson@peds.arizona.edu

Our previous genome-wide Quantitative Trait Locus (QTL) mapping study using mouse A/J by C57BL/6J recombinant inbred (RI) lines suggested several chromosomal regions contain genes influencing susceptibility to phenytoin (PT)-induced cleft lip with or without cleft palate [CL(P)] and 6-aminonicotinamide (6-AN)-induced isolated cleft palate (CP). Importantly, the same chromosomal regions but different RI parental strain alleles were sometimes implicated in susceptibility to these different kinds of orofacial clefting. Here we report the susceptibility to hydrocortisone (HC)-induced CP in these RI lines. We treated pregnant females with HC and studied the incidence of CP in day 17 fetuses. RI lines showed highly correlated responses to HC and 6-AN. The A/J parental line and five RI lines showed very high levels of clefting in response to both of these teratogens. The C57BL/6J parental line and five other RI lines exhibited low incidence of CP for these teratogens. In contrast, there was no significant correlation between incidence of PT-induced CL(P) and HC-induced CP.

Published 13 April 2005 in Life Sci, 76(18): 2071-8.
Full-text of this article is available online (may require subscription).

© 2005-2008 Cleft Palate Research Today. All Rights Reserved.